The Opposite Metabolic Effects of Erythropoietin and U-74389Gon Serum Alanine Amino Transferase Levels

Aim:This study calculated the metabolic capacities of 2 drugs: the erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G on serum alanine amino transferees (ALT) levels. The calculation was based on the results of 2 preliminary studies, each one of which estimated the influence on (ALTl) levels, after the respective drug usage in an induced ischemia reperfusion animal experiment. Materials and methods: The 2 main experimental endpoints at which the ALTl were evaluated was the 60th reperfusion min (for the groups A, C and E) and the 120th reperfusion min (for the groups B, D and F). Specially, the groups A and B were processed without drugs, groups C and D after Epo administration; whereas groups E and F after the L administration. Results:The first preliminary study of Epo presented a non significant alanine hyper amino transfer asemic effect by 8.04%+11.37% (p=-value=0.4698). The second preliminary study of U-74389G presented a non significant alanine hypo amino transferasemic effect by 4.99%+6.79% (p-value=0.4527). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation of these 2 drugs, as easily can be perceived, is that have opposite effects on ALTL. Conclusion:The anti-oxidant capacities of U-74389G ascribe opposite metabolic effects than Epo on ALTl.

Keywords: ischemia; erythropoietin; U-74389G; serum alanine amino transferees levels; reperfusion.